Core and sialylated O glycan standards

Oxford, February 2015

O-glycosylation is a common covalent modification of serine and threonine residues of mammalian glycoproteins. In O-glycans, the first monosaccharide attached in the synthesis is α-linked N-acetyl-galactosamine (GalNac). A Core 1 structure is generated by the addition of galactose to this. A Core 2 structure is generated by the further addition of N-acetyl-glucosamine to the N-acetyl-galactosamine of the Core 1 structure. In total there are eight different core structures and all can be sialylated.

Core 1 and Core 2 glycans are found in many glycoproteins and mucins (proteins conjugated to carbohydrate). They are also present in biopharmaceuticals (e.g. EPO).

Six 2-AB labeled Core 1 and Core 2 O glycan standards are now available. The standards typically have a purity of > 93% as assessed by HILIC-HPLC.

This product is for customers working with biopharmaceuticals and it can also be used to study biomarkers. 2-AB labelled O-glycan standards can be used as internal references or system suitability standards for the peak assignment during HPLC or UPLC analysis.

Product Info:

Description Cat# Quantity
2AB labeled core 1 O glycan CAB-C1-01  100pmol
2AB labeled di-sialylated core 2 O glycan CAB-C2S(3,3)2-01    100pmol
2AB labeled di-sialylated core 2 O glycan CAB-C2S(3,3)2-02  50pmol
2AB labeled sialylated core 1 O glycan CAB-C1S(3)1-01  100pmol
2AB labeled sialylated core 1 O glycan CAB-C1S(3)1-02  50pmol
2AB labeled di-sialylated core 1 O glycan CAB-C1S(3,6)2-01  100pmol

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